OBJECTIVE: Interleukin-6 (IL-6) is expressed in osteoarthritic joints but its function in
osteoarthritis (OA) is unknown. To study this, spontaneous and experimental OA were …

Summary Objective Interleukin-1 (IL-1) is an alleged important cytokine in osteoarthritis
(OA), although the exact contribution of IL-1 to joint destruction remains unclear. Here we …

Interleukin-6 (IL-6) plays a key role in the local and systemic manifestations of rheumatoid
arthritis (RA). IL-6 is not only a proinflammatory cytokine, but also interacts in complex ways …

Objective Osteoarthritis (OA), the leading cause of joint failure, is characterized by
breakdown of articular cartilage and remodeling of subchondral bone in synovial joints …

Osteoarthritis (OA) is closely related to the function of several inflammatory cytokines. It has
been reported that older age is associated with higher serum levels of the inflammatory …

Background and purpose Little is known about biochemical mediators that correlate with the
initiation and progression of knee osteoarthritis (OA). We therefore valuated the roles of …

Background In osteoarthritis (OA), an inflammatory environment is responsible for the
imbalance between the anabolic and catabolic activity of chondrocytes and, thus, for …

Introduction Fibronectin fragments have been found in the articular cartilage and synovial
fluid of patients with osteoarthritis and rheumatoid arthritis. These matrix fragments can …

As a main cause of morbidity in the aged population, osteoarthritis (OA) is characterized by
cartilage destruction, synovium inflammation, osteophytes, and subchondral bone sclerosis …

Objective Interleukin‐10 (IL‐10) is a pleiotropic immunoregulatory cytokine with a
chondroprotective effect that is elevated in cartilage and synovium in patients with …