The ability to predict hepatic metabolic clearance is a key component in the design and
selection of small molecule drug candidates within the pharmaceutical industry. The …

Objectives Membrane transporters and metabolism are major determinants of the
hepatobiliary elimination of drugs. This work investigates several key questions for drug …

Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …

Introduction: The key role of transporter biology in both the manifestation and treatment of
disease is now firmly established. Experiences of sub-optimal drug exposure due to drug …

Recent studies of membrane transporters have revealed their importance in determining the
pharmacokinetics of transporter substrates. When drug-drug interactions (DDIs) or genetic …

Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …

The interdependence of both transport and metabolism on the disposition of drugs has
recently gained heightened attention in the literature, and has been termed the “interplay of …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

Both metabolizing enzymes and drug transporters play important roles in modulating drug
absorption, distribution, metabolism and elimination. Acting alone or in concert with each …