Microtubule-depolymerizing kinesins in the regulation of assembly, disassembly, and length of cilia and flagella

Z Hu, Y Liang, D Meng, L Wang, J Pan - International review of cell and …, 2015 - Elsevier
Defects in ciliary assembly, maintenance, and signaling are associated with various human
diseases and developmental disorders, termed ciliopathies. Eukaryotic flagella and cilia …

Ciliary kinesins beyond IFT: cilium length, disassembly, cargo transport and signalling

ML Reilly, A Benmerah - Biology of the Cell, 2019 - Wiley Online Library
Cilia and flagella are microtubule‐based antenna which are highly conserved among
eukaryotes. In vertebrates, primary and motile cilia have evolved to exert several key …

A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas

T Piao, M Luo, L Wang, Y Guo, D Li… - Proceedings of the …, 2009 - National Acad Sciences
Cilia and flagella are dynamic organelles that are assembled and disassembled during cell
differentiation, during stress, and during the cell cycle. Although intraflagellar transport (IFT) …

The C‐terminal tails of heterotrimeric kinesin‐2 motor subunits directly bind to α‐tubulin1: Possible implications for cilia‐specific tubulin entry

M Girotra, S Srivastava, A Kulkarni, A Barbora, K Bobra… - Traffic, 2017 - Wiley Online Library
The assembly of microtubule‐based cytoskeleton propels the cilia and flagella growth.
Previous studies have indicated that the kinesin‐2 family motors transport tubulin into the …

Kinesin motors and primary cilia

KJ Verhey, J Dishinger, HL Kee - Biochemical Society …, 2011 - portlandpress.com
Cilia and flagella play important roles in human health by contributing to cellular motility as
well as sensing and responding to environmental cues. Defects in ciliary assembly and/or …

A novel microtubule-depolymerizing kinesin involved in length control of a eukaryotic flagellum

C Blaineau, M Tessier, P Dubessay, L Tasse, L Crobu… - Current Biology, 2007 - cell.com
Cilia and flagella are complex, microtubule (MT)-filled cell organelles of which the structure
is evolutionarily conserved from protistan cells to mammalian sperm and the size is …

Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins

SK Morthorst, ST Christensen… - The FEBS journal, 2018 - Wiley Online Library
Primary cilia are antenna‐like sensory organelles that regulate a substantial number of
cellular signalling pathways in vertebrates, both during embryonic development as well as in …

Kinesin-13 regulates the quantity and quality of tubulin inside cilia

KK Vasudevan, YY Jiang, KF Lechtreck… - Molecular biology of …, 2015 - Am Soc Cell Biol
Kinesin-13, an end depolymerizer of cytoplasmic and spindle microtubules, also affects the
length of cilia. However, in different models, depletion of kinesin-13 either lengthens or …

Who drives the ciliary highway?

J Malicki - Bioarchitecture, 2012 - Taylor & Francis
Cilia are protrusions on the surface of cells. They are frequently motile and function to propel
cells in an aqueous environment or to generate fluid flow. Equally important is the role of …

Flagellar kinesins in protists

W Marande, L Kohl - Future microbiology, 2011 - Taylor & Francis
Cilia and flagella are organelles of the cell body present in many eukaryotic cells. Although
their basic structure is well conserved from unicellular organisms to mammals, they show …