Objective: Using microarray technique we analysed global changes in gene expression of
interferon-γ treated primary macrophages. Among the differential expressed genes identified …

Transporter associated with Ag processing 1 and low molecular mass polypeptide 2 (LMP2)
are essential for class I MHC function and share a common bidirectional promoter. In murine …

The genes of the transporter associated with antigen processing (Tap)-1, and the low
molecular weight peptide (Lmp)-2, are crucial for class I major histocompatibility complex …

The adaptive immune systems have evolved to protect the organism against pathogens
encountering the host. Extracellular occurring viruses or bacteria are mainly bound by …

The MHC class I molecules present antigenic peptides to CTL. The peptides are delivered to
the secretory pathway by TAP, which is formed by the association of MHC-encoded TAP1 …

The transporter associated with antigen processing (TAP) gene products is involved in the
processing of endogenous peptides that bind to MHC class I molecules. Mutations and/or …

Human cytotoxic T lymphocytes (CTL) recognize specific complexes of HLA class I
molecules and peptides, which assemble when nascent class I molecules bind peptides …

Background The transporter associated with antigen processing (TAP), a member of the
family of ABC transporters, plays a crucial role in the processing and presentation of the …

The transporter associated with antigen presentation (TAP) is an ATP-binding cassette
(ABC) protein which transports peptides for presentation to the immune system. TAP is …

With recent studies suggesting a key role for professional antigen presenting cells in the
induction of major histocompatibility class I cellular immune responses, we initiated studies …