The integrated landscape of causal genes and pathways in schizophrenia

C Ma, C Gu, Y Huo, X Li, XJ Luo - Translational psychiatry, 2018 - nature.com
Genome-wide association studies (GWAS) have identified more than 100 loci that show
robust association with schizophrenia risk. However, due to the complexity of linkage …

Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia

P Jia, L Wang, AH Fanous, CN Pato… - PLoS computational …, 2012 - journals.plos.org
With the recent success of genome-wide association studies (GWAS), a wealth of
association data has been accomplished for more than 200 complex diseases/traits …

Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

CP Yang, X Li, Y Wu, Q Shen, Y Zeng, Q Xiong… - Nature …, 2018 - nature.com
Recent genome-wide association studies (GWAS) have identified multiple risk loci that show
strong associations with schizophrenia. However, pinpointing the potential causal genes at …

Functional genomics identify a regulatory risk variation rs4420550 in the 16p11. 2 schizophrenia-associated locus

H Chang, X Cai, HJ Li, WP Liu, LJ Zhao, CY Zhang… - Biological …, 2021 - Elsevier
Background Genome-wide association studies (GWASs) have reported hundreds of
genomic loci associated with schizophrenia, yet identifying the functional risk variations is a …

Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk

Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …

Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia

J Liu, S Li, X Li, W Li, Y Yang, S Guo, L Lv, X Xiao… - BMC medicine, 2021 - Springer
Background Over 200 schizophrenia risk loci have been identified by genome-wide
association studies (GWASs). However, the majority of risk loci were identified in …

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Integrated post-GWAS analysis sheds new light on the disease mechanisms of schizophrenia

JR Lin, Y Cai, Q Zhang, W Zhang… - Genetics, 2016 - academic.oup.com
Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-
wide association studies (GWAS) have identified many schizophrenia-associated common …

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling

D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
Large-scale genome-wide association studies (GWAS) have implicated many low-
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …

Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia

JQ Wu, X Wang, NJ Beveridge, PA Tooney, RJ Scott… - PloS one, 2012 - journals.plos.org
Background While hybridization based analysis of the cortical transcriptome has provided
important insight into the neuropathology of schizophrenia, it represents a restricted view of …