BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …

Background and objectives Phenotypic switching in vascular smooth muscle cells (VSMCs)
has been linked to aortic aneurysm, but the phenotypic landscape in aortic aneurysm is …

Objective—Recent studies suggested the occurrence of phenotypic switching of vascular
smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However …

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Background: Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic
smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly lethal …

Abstract Background and Aims Stanford type A aortic dissection (AD) is a degenerative
aortic remodelling disease marked by an exceedingly high mortality without effective …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Rationale: While cell-cell interaction plays a critical role in physiology and disease, a
comprehensive understanding of its dynamics in vascular homeostasis and diseases is yet …

The etiology of aortic aneurysms is poorly understood, but it is associated with
atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) …