Plasmid co-infection: linking biological mechanisms to ecological and evolutionary dynamics

C Igler, JS Huisman, B Siedentop… - … of the Royal …, 2022 - royalsocietypublishing.org
As infectious agents of bacteria and vehicles of horizontal gene transfer, plasmids play a key
role in bacterial ecology and evolution. Plasmid dynamics are shaped not only by plasmid …

The evolution of plasmid stability: Are infectious transmission and compensatory evolution competing evolutionary trajectories?

JPJ Hall, MA Brockhurst, C Dytham, E Harrison - Plasmid, 2017 - Elsevier
Conjugative plasmids are widespread and play an important role in bacterial evolution by
accelerating adaptation through horizontal gene transfer. However, explaining the long-term …

Mathematical models of plasmid population dynamics

JCR Hernández-Beltrán, A San Millán… - Frontiers in …, 2021 - frontiersin.org
With plasmid-mediated antibiotic resistance thriving and threatening to become a serious
public health problem, it is paramount to increase our understanding of the forces that …

Plasmid viability depends on the ecological setting of hosts within a multiplasmid community

C Given, R Penttinen, M Jalasvuori - Microbiology Spectrum, 2022 - Am Soc Microbiol
Plasmids are extrachromosomal genetic elements, some of which disperse horizontally
between different strains and species of bacteria. They are a major factor in the …

The interplay between relatedness and horizontal gene transfer drives the evolution of plasmid-carried public goods

SÉ Mc Ginty, L Lehmann… - Proceedings of the …, 2013 - royalsocietypublishing.org
Plasmids carry a wide range of genes that are often involved in bacterial social behaviour.
The question of why such genes are frequently mobile has received increasing attention …

Impact of plasmid interactions with the chromosome and other plasmids on the spread of antibiotic resistance

JA Gama, R Zilhão, F Dionisio - Plasmid, 2018 - Elsevier
Naturally occurring plasmids have medical importance given that they frequently code for
virulence or antibiotic resistance. In many cases, plasmids impose a fitness cost to their …

Modeling the ecology of parasitic plasmids

JG Lopez, MS Donia, NS Wingreen - The ISME Journal, 2021 - academic.oup.com
Plasmids are autonomous genetic elements that can be exchanged between
microorganisms via horizontal gene transfer (HGT). Despite the central role they play in …

Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations

A San Millan, K Heilbron, RC MacLean - The ISME journal, 2014 - academic.oup.com
Plasmids have a key role in the horizontal transfer of genes among bacteria. Although
plasmids are catalysts for bacterial evolution, it is challenging to understand how they can …

The dilution effect limits plasmid horizontal transmission in multispecies bacterial communities

A Kottara, L Carrilero, E Harrison, JPJ Hall… - …, 2021 - microbiologyresearch.org
By transferring ecologically important traits between species, plasmids drive genomic
divergence and evolutionary innovation in their bacterial hosts. Bacterial communities are …

Natural selection, infectious transfer and the existence conditions for bacterial plasmids

CT Bergstrom, M Lipsitch, BR Levin - Genetics, 2000 - academic.oup.com
Despite the near-ubiquity of plasmids in bacterial populations and the profound contribution
of infectious gene transfer to the adaptation and evolution of bacteria, the mechanisms …