Influenza infection, SARS, MERS and COVID-19: cytokine storm–the common denominator and the lessons to be learned

VA Ryabkova, LP Churilov, Y Shoenfeld - Clinical Immunology, 2021 - Elsevier
The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus
infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin …

On the alert for cytokine storm: immunopathology in COVID‐19

LA Henderson, SW Canna, GS Schulert… - Arthritis & …, 2020 - Wiley Online Library
Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …

Macrophage activation syndrome and COVID-19

R Otsuka, K Seino - Inflammation and regeneration, 2020 - Springer
An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating
pandemic. As we have not developed curative medicine and effective vaccine, the end of …

Could SARS-CoV-2-induced hyperinflammation magnify the severity of coronavirus disease (CoViD-19) leading to acute respiratory distress syndrome?

ASS Girija, EM Shankar, M Larsson - Frontiers in immunology, 2020 - frontiersin.org
The exaggerated immune response induced in the lower respiratory tract against
coronaviruses (CoVs), including CoViD-19 (2019-nCoV), appears to contribute to the …

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …

Cytokine storm syndrome in coronavirus disease 2019: A narrative review

YM Gao, G Xu, B Wang, BC Liu - Journal of internal medicine, 2021 - Wiley Online Library
Cytokine storm syndrome (CSS) is a critical clinical condition induced by a cascade of
cytokine activation, characterized by overwhelming systemic inflammation …

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
ABSTRACT SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19
patients experience sudden and rapid deterioration with the onset of fatal cytokine storm …

Weathering the COVID-19 storm: lessons from hematologic cytokine syndromes

JT England, A Abdulla, CM Biggs, AYY Lee, KA Hay… - Blood Reviews, 2021 - Elsevier
A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …

[PDF][PDF] Discrimination of COVID‐19 from inflammation‐induced cytokine storm syndromes using disease‐related blood biomarkers

C Kessel, R Vollenberg… - Arthritis & …, 2021 - Wiley Online Library
Objective Infection with the novel coronavirus SARS–CoV‐2 triggers severe illness with high
mortality in a subgroup of patients. Such a critical course of COVID‐19 is thought to be …

Preliminary predictive criteria for COVID-19 cytokine storm

R Caricchio, M Gallucci, C Dass, X Zhang… - Annals of the …, 2021 - ard.bmj.com
Objectives To develop predictive criteria for COVID-19-associated cytokine storm (CS), a
severe hyperimmune response that results in organ damage in some patients infected with …