Immune alterations in a patient with SARS-CoV-2-related acute respiratory distress syndrome

L Bouadma, A Wiedemann, J Patrier… - Journal of clinical …, 2020 - Springer
We report a longitudinal analysis of the immune response associated with a fatal case of
COVID-19 in Europe. This patient exhibited a rapid evolution towards multiorgan failure …

[PDF][PDF] Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

SA Lowery, A Sariol, S Perlman - Cell host & microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …

Cytokine storm and the prospects for immunotherapy with COVID-19.

LH Calabrese - Cleveland Clinic journal of medicine, 2020 - europepmc.org
Knowledge about the pathobiology of SARS-CoV-2 as it interacts with immune defenses is
limited. SARS-CoV-2 is spread by droplets that come into contact with mucous membranes …

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

S Makaremi, A Asgarzadeh, H Kianfar… - Inflammation …, 2022 - Springer
A global pandemic has erupted as a result of the new brand coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …

SARS‐CoV‐2‐mediated immune system activation and potential application in immunotherapy

Y Tan, F Tang - Medicinal research reviews, 2021 - Wiley Online Library
Although novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐mediated
pulmonary inflammation has recently attracted great attention, its pathology and …

[HTML][HTML] IL-6 modulation for COVID-19: the right patients at the right time?

PA Ascierto, B Fu, H Wei - Journal for immunotherapy of cancer, 2021 - ncbi.nlm.nih.gov
The ongoing pandemic caused by the novel coronavirus SARS-CoV-2 has disrupted the
global economy and strained healthcare systems to their limits. After the virus first emerged …

[PDF][PDF] The innate immune system: fighting on the front lines or fanning the flames of COVID-19?

JL McKechnie, CA Blish - Cell host & microbe, 2020 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had
devastating global impacts and will continue to have dramatic effects on public health for …

COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive
production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical …

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

M Blot, JB Bour, JP Quenot, A Bourredjem… - Journal of translational …, 2020 - Springer
Background Although immune modulation is a promising therapeutic avenue in coronavirus
disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has …