A comprehensive approach to modeling maternal immune activation in rodents

MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …

Advancing autism research from mice to marmosets: Behavioral development of offspring following prenatal maternal immune activation

D Santana-Coelho, D Layne-Colon… - Frontiers in …, 2021 - frontiersin.org
Understanding the mechanism (s) by which maternal immune activation (MIA) during
gestation may disrupt neurodevelopment and increase the susceptibility for disorders such …

[HTML][HTML] Maternal immune activation in rodent models: A systematic review of neurodevelopmental changes in gene expression and epigenetic modulation in the …

RM Woods, JM Lorusso, HG Potter, JC Neill… - Neuroscience & …, 2021 - Elsevier
Maternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …

[HTML][HTML] Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model

MD Bauman, J Van de Water - Neurobiology of disease, 2020 - Elsevier
The prenatal environment, and in particular, the maternal-fetal immune environment, has
emerged as a targeted area of research for central nervous system (CNS) diseases with …

Maternal immune activation and related factors in the risk of offspring psychiatric disorders

F Conway, AS Brown - Frontiers in psychiatry, 2019 - frontiersin.org
Maternal immune activation (MIA) at the time of gestation has been linked to increased risk
of neurodevelopmental psychiatric disorders. Animal and human models have been used to …

Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in …

MB Hall, DE Willis, EL Rodriguez… - Frontiers in …, 2023 - frontiersin.org
Epidemiological evidence suggests that one's risk of being diagnosed with a
neurodevelopmental disorder (NDD)—such as autism, ADHD, or schizophrenia—increases …

Maternal immune activation in neurodevelopmental disorders

CM Solek, N Farooqi, M Verly, TK Lim… - Developmental …, 2018 - Wiley Online Library
Converging lines of evidence from basic science and clinical studies suggest a relationship
between maternal immune activation (MIA) and neurodevelopmental disorders such as …

Maternal immune activation during pregnancy alters postnatal brain growth and cognitive development in nonhuman primate offspring

RM Vlasova, AM Iosif, AM Ryan, LH Funk… - Journal of …, 2021 - Soc Neuroscience
Human epidemiological studies implicate exposure to infection during gestation in the
etiology of neurodevelopmental disorders. Animal models of maternal immune activation …

Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment

E Guma, M Bordeleau… - Proceedings of the …, 2022 - National Acad Sciences
Exposure to maternal immune activation (MIA) in utero is a risk factor for
neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult …

The impact of maternal immune activation on embryonic brain development

F McEwan, JD Glazier, R Hager - Frontiers in Neuroscience, 2023 - frontiersin.org
The adult brain is a complex structure with distinct functional sub-regions, which are
generated from an initial pool of neural epithelial cells within the embryo. This transition …