Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose
metabolism, besides reducing glucose to sorbitol, reduces a number of lipid peroxidation …

Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …

Aldose Reductase (ALR2) is defined as the first enzyme of the “polyol pathway”. As such,
ALR2 would convert glucose to sorbitol through an NADPH dependent reaction. Considered …

Aldose reductase [ALR2; EC 1.1. 1.21], a key enzyme of polyol pathway, catalyzes NADPH-
dependent reduction of glucose to sorbitol (Sorbitol pathway), and an excessive …

Aldose reductase (AR) is an aldo–keto reductase that has been widely investigated as an
enzyme crucially involved in the pathogenesis of chronic complications associated with …

Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The reduction
of glucose by the AR-catalyzed polyol pathway has been linked to the development of …

Introduction: Aldose reductase (AR) was initially thought to be involved in the secondary
diabetic complications because of its glucose-reducing potential. However, evidence from …

Aldose reductase enzyme (ALR2) of the polyol metabolic pathway, apart from its role as
detoxifying enzyme towards toxic aldehydes, osmoregulator in the kidney and regulator of …

In the past years aldose reductase (AKR1B1; AR) is thought to be involved in the
pathogenesis of secondary diabetic complications such as retinopathy, neuropathy …

Aldose reductase (AR) is an NADPH-dependent enzyme that catalyses the reduction of the
aldehyde to the corresponding alcohols. Diabetic complications including neuropathy …