Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes the papain-like
protease (PLpro). The protein not only plays an essential role in viral replication but also …

Global public health has been a critical problem by the sudden increase of the COVID-19
outbreak. The papain-like protease (PLpro) of SARS-CoV-2 is a key promising target for …

As an extension of our research against COVID-19, a multiphase in silico approach was
applied in the selection of the three most common inhibitors (Glycyrrhizoflavone (76) …

Using the crystal structure of SARS-CoV-2 papain-like protease (PL pro) as a template, we
developed a pharmacophore model of functional centers of the PL pro inhibitor-binding …

In the absence of an approved vaccine, developing effective severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) antivirals is essential to tackle the current pandemic …

The papain-like protease (PL pro) is vital for the replication of coronaviruses (CoVs), as well
as for escaping innate-immune responses of the host. Hence, it has emerged as an …

The rapid global spread of the SARS-CoV-2 virus facilitated the development of novel direct-
acting antiviral agents (DAAs). The papain-like protease (PLpro) has been proposed as one …

COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political,
socio-economic, and public health consequences. Inhibiting replication represents an …

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with very limited treatments so far …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses a
multifunctional papain-like proteinase (PLpro), which mediates the processing of the viral …