K18-hACE2 mice for studies of COVID-19 treatments and pathogenesis including anosmia

J Zheng, LY Roy Wong, K Li, AK Verma, M Ortiz… - BioRxiv, 2020 - biorxiv.org
The ongoing COVID-19 pandemic is associated with substantial morbidity and mortality.
While much has been learned in the first months of the pandemic, many features of COVID …

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

J Zheng, LYR Wong, K Li, AK Verma, ME Ortiz… - Nature, 2021 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial
morbidity and mortality. Although much has been learned in the first few months of the …

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - Nature …, 2023 - nature.com
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

Recovery of anosmia in hamsters infected with SARS-CoV-2 is correlated with repair of the olfactory epithelium

RA Reyna, M Kishimoto-Urata, S Urata, T Makishima… - Scientific reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for a
pandemic affecting billions of people worldwide. Apart from the extreme global economic …

[PDF][PDF] COVID-19: disCOVering the role of complement system

P Conigliaro, P Triggianese, C Perricone… - Clin Exp …, 2020 - clinexprheumatol.org
Complement system in COVID-19/P. Conigliaro et al. ed that in H5N1-infected mice the ALI
was related with an abnormal activation of CS in lung tissue. In H5N1-infected mice, the …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model

RA Reyna, J Walker, B Mitchell, DP Shinde, JA Plante… - Vaccines, 2023 - mdpi.com
Anosmia, a total or partial loss of the ability to smell, is one of the most frequently
documented sequelae of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

V Fumagalli, M Ravà, D Marotta, P Di Lucia… - Science …, 2021 - science.org
The development of a tractable small animal model faithfully reproducing human
coronavirus disease 2019 pathogenesis would arguably meet a pressing need in …

Author Correction: Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - nature …, 2023 - ncbi.nlm.nih.gov
The original version read “Here we show that all evaluated SARS-CoV-2 viruses (Wuhan,
Gamma, Delta and Omicron/BA. 1), including novel generated recombinant SARS-CoV-2 …

Human convalescent plasma protects K18-hACE2 mice against severe respiratory disease

JW Golden, X Zeng, CR Cline… - Journal of General …, 2021 - microbiologyresearch.org
SARS-CoV-2 is the causative agent of COVID-19 and human infections have resulted in a
global health emergency. Small animal models that reproduce key elements of SARS-CoV-2 …