Reduced modulation of BOLD variability as a function of cognitive load in healthy aging

JR Rieck, B DeSouza, G Baracchini, CL Grady - Neurobiology of Aging, 2022 - Elsevier
BOLD variability, which measures moment-to-moment fluctuations in brain signal, is
sensitive to age differences in cognitive performance. However, the effect of aging on BOLD …

Greater BOLD variability is associated with poorer cognitive function in an adult lifespan sample

MA Boylan, CM Foster, EE Pongpipat, CE Webb… - Cerebral …, 2021 - academic.oup.com
Moment-to-moment fluctuations in brain signal assessed by functional magnetic resonance
imaging blood oxygenation level dependent (BOLD) variability is increasingly thought to …

The modulation of BOLD variability between cognitive states varies by age and processing speed

DD Garrett, N Kovacevic, AR McIntosh… - Cerebral cortex, 2013 - academic.oup.com
Increasing evidence suggests that brain variability plays a number of important functional
roles for neural systems. However, the relationship between brain variability and changing …

Moment-to-moment BOLD signal variability reflects regional changes in neural flexibility across the lifespan

JS Nomi, TS Bolt, CEC Ezie, LQ Uddin… - Journal of …, 2017 - Soc Neuroscience
Variability of neuronal responses is thought to underlie flexible and optimal brain function.
Because previous work investigating BOLD signal variability has been conducted within task …

BOLD variability is related to dopaminergic neurotransmission and cognitive aging

M Guitart-Masip, A Salami, D Garrett… - Cerebral …, 2016 - academic.oup.com
Dopamine (DA) losses are associated with various aging-related cognitive deficits. Typically,
higher moment-to-moment brain signal variability in large-scale patterns of voxels in …

Dynamic range in BOLD modulation: lifespan aging trajectories and association with performance

KM Kennedy, MA Boylan, JR Rieck, CM Foster… - Neurobiology of …, 2017 - Elsevier
Alteration of dynamic range of modulation to cognitive difficulty has been proposed as a
salient predictor of cognitive aging. Here, we examine in 171 adults (aged 20–94 years) the …

Brain signal variability is modulated as a function of internal and external demand in younger and older adults

CL Grady, DD Garrett - Neuroimage, 2018 - Elsevier
Abstract Variability in the Blood Oxygen-Level Dependent (BOLD) signal from fMRI is often
associated with better cognitive performance and younger age. It has been proposed that …

Dynamic range of frontoparietal functional modulation is associated with working memory capacity limitations in older adults

JG Hakun, NF Johnson - Brain and cognition, 2017 - Elsevier
Older adults tend to over-activate regions throughout frontoparietal cortices and exhibit a
reduced range of functional modulation during WM task performance compared to younger …

Lost dynamics and the dynamics of loss: longitudinal compression of brain signal variability is coupled with declines in functional integration and cognitive …

DD Garrett, A Skowron, S Wiegert, J Adolf… - Cerebral …, 2021 - academic.oup.com
Reduced moment-to-moment blood oxygen level-dependent (BOLD) signal variability has
been consistently linked to advanced age and poorer cognitive performance, showing …

Within-Individual BOLD Signal Variability and its Implications for Task-Based Cognition: A Systematic Review

SN Steinberg, TZ King - Neuropsychology Review, 2023 - Springer
Within-individual blood oxygen level-dependent (BOLD) signal variability, intrinsic moment-
to-moment signal fluctuations within a single individual in specific voxels across a given time …