While epidemiological studies leave no doubt that there is an increased frequency of most
human cancers with increasing age, the molecular basis of these observations has not been …

In humans, telomere length in proliferating tissues shortens with age—a process
accelerated with age-related diseases. Thus, telomere length and attrition with age in the …

Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …

Long-lived organisms such as humans have evolved several intrinsic tumour suppressor
mechanisms to combat the slew of oncogenic somatic mutations that constantly arise in …

Neurodegenerative diseases associated with old age such as Alzheimer's disease present
major problems for society, and they currently have no cure. The telomere protective caps at …

Telomeres are repetitive DNA sequences at the ends of linear chromosomes. Telomerase, a
cellular reverse transcriptase, helps maintain telomere length in human stem cells …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Programmed telomere shortening in human somatic cells is thought to act as a tumor
suppressor pathway, limiting the replicative potential of developing tumor cells. Critically …

Normal somatic cells have a finite replicative capacity. With each cell division, telomeres, the
ends of linear chromosomes, progressively shorten until they reach a critical length, at which …

Replicative senescence is accompanied by a telomere‐specific DNA damage response
(DDR). We found that DDR+ telomeres occur spontaneously in early‐passage normal …