Pesticides affect different organs and tissues according to their bioavailability, chemical
properties and further molecular interactions. In animal models exposed to several classes …

The organophosphate pesticides exhibit their action by inhibiting acetylcholinesterase
(AChE) enzyme in central and peripheral nervous system. They are known to affect the …

The objective of this investigation was to determine the distribution of cholinergic and
noncholinergic biomarkers in discrete brain regions (cortex, stem, striatum, hippocampus …

[Frontiers in Bioscience 13, 1240-1249, January 1, 2008] 1240 Neurotoxicity of pesticides: a
brief review Lucio G. Costa1,2, Ge Page 1 [Frontiers in Bioscience 13, 1240-1249, January 1 …

The inhibition of acetylcholinesterase (AChE) has pharmaceutical applications as well as
potential neurotoxic effects. The in vivo metabolites of some chemicals including …

Background: Human exposure to insecticides raises serious public health concerns
worldwide. Insecticides constitute a wide-ranging heterogeneous group of chemicals, most …

Acetylcholinesterase (AChE) is a key enzyme in the nervous system. It terminates nerve
impulses by catalysing the hydrolysis of neurotransmitter acetylcholine. As a specific …

Among the numerous pesticides, anticholinesterase compounds are widely used. Their
toxicity induced by cholinesterase inhibition at the synapses and neuromuscular junctions …

Acute or chronic exposures to pesticides have been linked to neurotoxicity and the potential
development of neurodegenerative diseases (NDDs). This study aimed to consider the …

Several pesticides such as organophosphates, carbamates and the organochlorine
pesticides directly target nervous tissue as their mechanism of toxicity. In several others …