Twin studies and large-scale population studies have confirmed an increased sibling risk for
both Crohn's disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and …

Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …

Genetic, transcriptomic and epigenetic studies have offered exciting clues about IBD
pathogenesis but are unlikely to provide all answers. To fully grasp the function of disease …

Recent studies have greatly improved our insight into the genetic background of
inflammatory bowel disease (IBD). New high‐throughput technologies and large‐scale …

The influence of genetics in the etiology of inflammatory bowel disease (IBD) was initially
demonstrated by epidemiological data, including differences in prevalence among different …

Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory
bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations …

The genetic analysis of complex diseases has become a main-stream biomedical research
goal. The methods for genetically dissecting human diseases have now evolved into an …

The application of genetic information to diagnosis and risk prediction in inflammatory bowel
disease will require comprehensive knowledge of the relevant susceptibility alleles …

Regardless of how inflammatory bowel disease (IBD) is defined, the term “genetic
susceptibility” is always included. Due to substantial progress in the characterization of …

The genetic background of inflammatory bowel disease, both Crohn's disease and
ulcerative colitis, has been known for more than 2 decades. In the last 20 years, genome …