Monocular deprivation normally alters ocular dominance in the visual cortex only during a
postnatal critical period (20 to 32 days postnatal in mice). We find that mutations in the Nogo …

The closure of developmental critical periods consolidates neural circuitry but also limits
recovery from early abnormal sensory experience. Degrading vision by one eye throughout …

Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed
in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the …

Highlights•Nogo-A limits neural repair and recovery after adult CNS injuries.•NgR1 and
S1PR2 are receptors for different domains of Nogo-A.•Nogo-A and NgR1 limit experience …

Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in
myelin, Nogo and myelin-associated glycoprotein (MAG). The receptor for Nogo (NgR) has …

Mature retinal ganglion cells (RGCs), like other CNS neurons, cannot regrow injured axons
into a myelin-rich environment. If stimulated by macrophage-derived factors, however, RGCs …

Nogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting
axonal regeneration after central nervous system (CNS) injury. This review summarizes …

In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-
associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting …

Nogo-A, a membrane protein enriched in myelin of the adult CNS, inhibits neurite growth
and regeneration; neutralizing antibodies or receptor blockers enhance regeneration and …

In the adult mammalian CNS, the growth inhibitors oligodendrocyte-myelin glycoprotein
(OMgp) and the reticulon RTN4 (Nogo) are broadly expressed in oligodendrocytes and …