Introduction: Optimal management of severe sepsis in the ED has evolved rapidly. The
purpose of these guidelines is to review key management principles for Canadian …

Objective: The Canadian Association of Emergency Physicians (CAEP) sepsis guidelines
created by the CAEP Critical Care Practice Committee (C4) and published in the Canadian …

The Surviving Sepsis Campaign recently developed and published an updated version in
2012 of the international guidelines for the assessment and management of severe sepsis …

Although comprehensive guidelines for treatment of sepsis exist, current research continues
to refine and revise several aspects of management. Imperatives for rapid administration of …

Severe sepsis is a common and commonly fatal disease and is essentially an exaggerated
inflammatory response. The epidemiology of severe sepsis and septic shock has been …

PURPOSE: Mortality in severe sepsis and septic shock (SS/SS) remains high. Surviving
Sepsis Campaign (SSC) guidelines were published in 2004 with the goal of improving …

Increased attention has focused recently on the acute management of severe sepsis and
septic shock, conditions that represent the end-stage systemic deterioration of overwhelming …

Sepsis is the biggest challenge of our time facing emergency physicians. A recent editorial
in Journal of the American Medical Association [1] highlighted the substantial variation in …

Despite numerous advances in medicine, sepsis remains an unconquered challenge.
Although outcomes have improved slightly over decades, the unacceptably high mortality …

Severe sepsis is a syndrome characterised by systemic inflammation, coagulopathy and
acute organ dysfunction in response to an infection. 1 Worldwide, 18 million cases of severe …