Tryptophan is metabolized primarily via the kynurenine pathway (KP), which involves
several enzymes, including indoleamine 2, 3-dioxygenase, tryptophan 2, 3 dioxygenase …

The kynurenine pathway (KP) is the major route for tryptophan (TRP) metabolism in most
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …

Parkinson's disease (PD) is a complex multi-factorial neurodegenerative disorder where
various altered metabolic pathways contribute to the progression of the disease. Tryptophan …

The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

Background. There is substantial evidence that the kynurenine pathway (KP) plays a role in
the normal physiology of the brain and is involved in the pathology of neurodegenerative …

Kynurenine pathway is gaining more and more attention every day in biomedical research
since this catabolic route for tryptophan decomposition is not only implicated in different …

Background: A growing body of evidence has shown the involvement of the kynurenine
pathway (KP), the primary route of tryptophan (TRP) catabolism, in the pathophysiology of …

The kynurenine pathway (KP), which is activated in times of stress and infection has been
implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation …

Kynurenine aminotransferases (KATs) catalyze the synthesis of kynurenic acid (KYNA), an
endogenous antagonist of N-methyl-d-aspartate and alpha 7-nicotinic acetylcholine …

Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp)
degradation are reviewed. The KP accounts for~ 95% of dietary Trp degradation, of which …