Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

J Ge, R Wang, B Ju, Q Zhang, J Sun, P Chen… - Nature …, 2021 - nature.com
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the
development of effective therapeutics and vaccines. We recently isolated a large number of …

Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2

KYA Huang, X Chen, A Mohapatra, HTV Nguyen… - Nature …, 2023 - nature.com
Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection.
We isolated a panel of neutralizing anti-receptor-binding domain (RBD) antibodies elicited …

An engineered bispecific human monoclonal antibody against SARS-CoV-2

Z Li, S Li, G Zhang, W Peng, Z Chang, X Zhang… - Nature …, 2022 - nature.com
The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
requires effective therapies against coronavirus disease 2019 (COVID-19), and neutralizing …

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 …

Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern

IA Favorskaya, DV Shcheblyakov… - Frontiers in …, 2022 - frontiersin.org
Virus-neutralizing antibodies are one of the few treatment options for COVID-19. The
evolution of SARS-CoV-2 virus has led to the emergence of virus variants with reduced …

Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants

A Hao, W Song, C Li, X Zhang, C Tu, X Wang… - … and Targeted Therapy, 2023 - nature.com
In recent months, additional Omicron variants of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), including the BA. 5 sublineage BF. 7 and BQ. 1.1 and the BA …

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk… - Immunity, 2021 - cell.com
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased transmissibility and potential resistance, antibodies and vaccines …

[HTML][HTML] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

F Muecksch, Y Weisblum, CO Barnes, F Schmidt… - Immunity, 2021 - cell.com
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

H Liu, NC Wu, M Yuan, S Bangaru, JL Torres… - Immunity, 2020 - cell.com
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

KM Hastie, H Li, D Bedinger, SL Schendel… - Science, 2021 - science.org
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …