Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - Immunity, 2020 - cell.com
Antibody responses develop following SARS-CoV-2 infection, but little is known about their
epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We …

[HTML][HTML] BA. 2.12. 1, BA. 4 and BA. 5 escape antibodies elicited by Omicron infection

Y Cao, A Yisimayi, F Jian, W Song, T Xiao, L Wang… - Nature, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage 1. The receptor …

A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

T Onodera, S Kita, Y Adachi, S Moriyama, A Sato… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …

A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

T Noy-Porat, E Makdasi, R Alcalay, A Mechaly… - Nature …, 2020 - nature.com
The novel highly transmissible human coronavirus SARS-CoV-2 is the causative agent of
the COVID-19 pandemic. Thus far, there is no approved therapeutic drug specifically …

Rapid test to assess the escape of SARS-CoV-2 variants of concern

JT Heggestad, RJ Britton, DS Kinnamon, SA Wall… - Science …, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are concerning in
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, we developed a rapid …

Neutralization of SARS-CoV-2 Omicron BA. 2 by therapeutic monoclonal antibodies

H Zhou, T Tada, BM Dcosta, NR Landau - Biorxiv, 2022 - ncbi.nlm.nih.gov
Monoclonal antibody therapy for the treatment of SARS-CoV-2 infection has been highly
successful in decreasing disease severity; however, the recent emergence of the heavily …

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

A Wajnberg, F Amanat, A Firpo, DR Altman, MJ Bailey… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic with millions infected and more than 1 million fatalities. Questions regarding the …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

[HTML][HTML] Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

E Lopez, ER Haycroft, A Adair, FL Mordant, MT O'Neill… - JCI insight, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing
antibodies and one of the most rapidly evolving domains, which can result in the emergence …

A structural landscape of neutralizing antibodies against SARS-CoV-2 receptor binding domain

L Niu, KN Wittrock, GC Clabaugh, V Srivastava… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has
been spreading rampantly. The global scientific community has responded rapidly to …