Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

The presence of macrophages within the plaque is a defining hallmark of atherosclerosis.
Macrophages are exposed to various microenvironments such as oxidized lipids and …

Diversity and plasticity are hallmarks of mononuclear phagocytes, which are reflected in
plaque formation and evolution. Different monocyte subsets, which differentially contribute to …

Macrophages orchestrate the inflammatory response in inflamed tissues, and recent work
indicates that these cells can alter their phenotypes and functions accordingly in response to …

Initiation and progression of atherosclerosis depend on local inflammation and
accumulation of lipids in the vascular wall. Although many cells are involved in the …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Introduction• Current concepts in monocyte heterogeneity• Pro‐atherogenic role of plaque
macrophages• Anti‐atherogenic role of plaque macrophages• Macrophage heterogeneity …

Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local
proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial …

Atherosclerosis and associated cardiovascular disease are the leading causes of mortality
in developed countries and the World Health Organization has estimated that by 2020 these …