[HTML][HTML] Systems and synthetic biology-driven engineering of live bacterial therapeutics

K Kim, M Kang, BK Cho - Frontiers in Bioengineering and …, 2023 - frontiersin.org
The past decade has seen growing interest in bacterial engineering for therapeutically
relevant applications. While early efforts focused on repurposing genetically tractable model …

Engineering diagnostic and therapeutic gut bacteria

BP Landry, JJ Tabor - Bugs as Drugs: Therapeutic Microbes for …, 2018 - Wiley Online Library
Genetically engineered bacteria have the potential to diagnose and treat a wide range of
diseases linked to the gastrointestinal tract, or gut. Such engineered microbes will be less …

Engineered live biotherapeutics: progress and challenges

Y Tan, J Shen, T Si, CL Ho, Y Li, L Dai - Biotechnology Journal, 2020 - Wiley Online Library
The human microbiome plays an important role in human health, from metabolism to
immunity. In the last few decades, advances in synthetic biology have enabled scientists to …

Genetic engineering of resident bacteria in the gut microbiome

J Arnold, J Glazier, M Mimee - Journal of Bacteriology, 2023 - Am Soc Microbiol
Techniques by which to genetically manipulate members of the microbiota enable both the
evaluation of host-microbe interactions and an avenue by which to monitor and modulate …

Engineered bacteria as therapeutic agents

C Piñero-Lambea, D Ruano-Gallego… - Current opinion in …, 2015 - Elsevier
Highlights•Engineered bacteria provide a continuous supply of therapeutic
molecules.•Bacterial therapies target inflammation, immunity, cancer, and metabolic …

Engineering microbial living therapeutics: the synthetic biology toolbox

DB Pedrolli, NV Ribeiro, PN Squizato… - Trends in …, 2019 - cell.com
Microbes can be engineered to act like living therapeutics designed to perform specific
actions in the human body. From fighting and preventing infections to eliminating tumors and …

[HTML][HTML] Synthetic biology approaches in the development of engineered therapeutic microbes

M Kang, D Choe, K Kim, BK Cho, S Cho - International Journal of …, 2020 - mdpi.com
Since the intimate relationship between microbes and human health has been uncovered,
microbes have been in the spotlight as therapeutic targets for several diseases. Microbes …

Synthetic biology and the gut microbiome

J Dou, MR Bennett - Biotechnology journal, 2018 - Wiley Online Library
The gut microbiome plays a crucial role in maintaining human health. Functions performed
by gastrointestinal microbes range from regulating metabolism to modulating immune and …

[HTML][HTML] Synthetic biology and engineered live biotherapeutics: toward increasing system complexity

T Ozdemir, AJH Fedorec, T Danino, CP Barnes - Cell systems, 2018 - cell.com
Recent advances in synthetic biology and biological system engineering have allowed the
design and construction of engineered live biotherapeutics targeting a range of human …

Advances in synthetic biology toolboxes paving the way for mechanistic understanding and strain engineering of gut commensal Bacteroides spp. and Clostridium spp …

Y Tan, J Liang, M Lai, S Wan, X Luo, F Li - Biotechnology Advances, 2023 - Elsevier
The gut microbiota plays a significant role in influencing human immunity, metabolism,
development, and behavior by producing a wide range of metabolites. While there is …