Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

Work on obesity is evolving, and obesity is a consequence of our evolutionary history. In the
space of 50 years, we have become an obese species. The reasons why can be addressed …

Obesity is a complex multifaceted disease resulting from interactions between genetics and
lifestyle. The proportion of phenotypic variance ascribed to genetic variance is 0.4 to 0.7 for …

Obesity is an escalating threat of pandemic proportions, currently affecting billions of people
worldwide and exerting a devastating socioeconomic influence in industrialized countries …

Obesity has become a global epidemic and contributes to the increasing burden of type 2
diabetes, cardiovascular disease, stroke, some types of cancer, and premature death …

Multiple biological, behavioural and genetic determinants or correlates of obesity have been
identified to date. Genome-wide association studies (GWAS) have contributed to the …

The prevalence of obesity in modern societies has two major contributory factors—an
environmental change that has happened in historical times and a genetic predisposition …

Obesity and related complications are major health burdens. Almost 700 million adults are
currently obese globally and the prevalence is predicted to rise towards 2030. The sudden …

The prevalence of obesity has nearly doubled worldwide over the past three decades, but
substantial differences exist between nations. Although these differences are partly due to …