Developing novel drug formulations and progressing them to the clinical environment relies
on preclinical in vitro studies and animal tests to evaluate efficacy and toxicity. However …

A tumor microenvironment may promote tumor metastasis and progression through the
dynamic interplay between neoplastic cells and stromal cells. In this work, the most …

Microphysiological systems are in vitro tissue and organ models that present unique
opportunities across different disciplines, such as biology, medicine, and engineering …

Biomimicry of physiologically relevant microenvironments is a key challenge in simulating
pathological conditions in vitro. A plethora of organic and inorganic biomaterials have been …

Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ
biomimetic systems. OOC technology brings numerous advantages in the current landscape …

Microtechnology provides a new approach for reproducing the in vivo environment in vitro.
Mimicking the microenvironment of the natural tissues allows cultured cells to behave in a …

The high attrition rate of drug candidates late in the development process has led to an
increasing demand for test assays that predict clinical outcome better than conventional 2D …

The advances in microfluidic technology have recently generated various microfluidic-based
biomimetic models as novel three-dimensional (3D) models for life science research …

We have developed a simple multi-layer microfluidic device by integrating a polydimethyl
siloxane (PDMS) microfluidic channel and a porous membrane substrate to culture and …

Background Bioreactors are pivotal tools for generating mechanical stimulation in functional
tissue engineering study. This study aimed to create a bioreactor that can simulate urinary …