Few studies have examined in vivo virulence gene expression in Streptococcus
pneumoniae. In this study, expression of key pneumococcal virulence genes cbpA, pspA …

The polysaccharide capsule of Streptococcus pneumoniae and several well-characterized
virulence proteins are known to contribute to the pathogenesis of pneumococcal disease …

Colonization and persistence in the human nasopharynx are prerequisites for Streptococcus
pneumoniae disease and carriage acquisition, which normally occurs during early …

Pneumococcal disease continues to account for significant morbidity and mortality
worldwide. For the development of novel prophylactic and therapeutic strategies against the …

Streptococcus pneumoniae is the major cause of bacterial pneumonia, and it is also
responsible for otitis media and meningitis in children. Apart from the capsule, the virulence …

Streptococcus pneumoniae (the pneumococcus) is carried in the nasopharynx of healthy
individuals, but can spread to other host sites and lead to pneumonia, bacteraemia, otitis …

Streptococcus pneumoniae probably possesses a redundant set of factors required for
colonization of the nasopharynx and invasive disease, because of its strict relationship with …

Streptococcus pneumoniae infection starts from the respiratory tract where interaction with
host epithelial cells occurs. To gain more insights on pneumococcal pathogenesis, an …

Streptococcus pneumoniae (the pneumococcus) continues to be responsible for a high level
of global morbidity and mortality resulting from pneumonia, bacteremia, meningitis, and otitis …

We have previously shown that CbpA, a major pneumococcal virulence factor, is regulated
by the two-component signal transduction system RR/HK06 (AJ Standish, UH Stroeher, and …