The intestinal epithelial monolayer forms a transcellular and paracellular barrier that
separates luminal contents from the interstitium. The paracellular barrier consists of a highly …

Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …

Epithelia form barriers that are essential to life. This is particularly true in the intestine, where
the epithelial barrier supports nutrient and water transport while preventing microbial …

Tight junctions create a paracellular barrier that is essential for survival of complex
organisms. In many cases tight junctions define separate, generally sterile, tissue …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

Highlights•Paracellular flux is regulated by dynamic tight junction protein
interactions.•Claudin interactions define small molecule flux across tight junction pores.• …

Defective epithelial barrier function is present in maladies including epidermal burn injury,
environmental lung damage, renal tubular disease, and a range of immune-mediated and …

The major and rate-limiting barrier to transepithelial permeation in the intestine is the
intercellular tight junction. Tight junction structure is often cell type specific and general but …

Like all mucosal surfaces, the intestine forms a barrier that separates the external
environment, ie, the gut lumen, from the protected internal milieu. The intestinal barrier is …

Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …