Inflammasomes are cytosolic innate immune sensors of pathogen infection and cellular
damage that induce caspase-1–mediated inflammation upon activation. Although …

The NLRP3 inflammasome regulates innate immune and inflammatory responses by
promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main …

Following entry and replication of Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-
CoV-2) into ACE2 expressing cells, the infected cells undergo lysis releasing more virus but …

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …

Inflammasome activation is exclusively involved in sensing activation of innate immunity and
inflammatory response during viral infection. Accumulating evidence suggests that the …

Many infections and stress signals can rapidly activate the NLRP3 inflammasome to elicit
robust inflammatory responses. This activation requires a priming step, which is thought to …

The NLRP3 inflammasome is a critical component of innate immunity that defends the host
from microbial infections. However, its aberrant activation contributes to the pathogenesis of …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …

Abstract The NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome
is a multimolecular complex that plays a fundamental role in inflammation. Optimal activation …