There have been extensive research efforts to develop new strategies for bone tissue
engineering. These have mainly focused on vascularization during the development and …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

Successful cell-based tissue engineering requires a rapid and thorough vascularization in
order to ensure long-term implant survival and tissue integration. The vascularization of a …

Inadequate vascularization of engineered tissue constructs is a main challenge in
developing a clinically impactful therapy for large, complex, and recalcitrant bone defects. It …

Natural bone growth greatly depends on the precedent vascular network that supplies
oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

One of the major problems with bone tissue engineering is the development of a rapid
vascularization after implantation to supply the growing osteoblast cells with the nutrients to …

In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …