c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity
H Doya, S Ohtori, M Fujitani, T Saito, K Hata… - Biochemical and …, 2005 - Elsevier
Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …
Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse
G Manassero, IE Repetto, S Cobianchi… - Molecular …, 2012 - journals.sagepub.com
Background: Current tools for analgesia are often only partially successful, thus
investigations of new targets for pain therapy stimulate great interest. Consequent to …
investigations of new targets for pain therapy stimulate great interest. Consequent to …
Activation of JNK pathway in persistent pain
The c-Jun N-terminal kinase (JNK) is a stress-activated member of MAP kinase family. JNK
activation has been strongly implicated in inflammatory responses, neurodegeneration, and …
activation has been strongly implicated in inflammatory responses, neurodegeneration, and …
Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex
MG Liu, FK Zhang, SW Guo, LF Zhao, YY An, XY Cui… - Neuroscience …, 2007 - Elsevier
The present study was undertaken to investigate whether isoforms of c-Jun N-terminal
kinase (JNK 46kDa and 54kDa), one component of the mitogen-activated protein kinase …
kinase (JNK 46kDa and 54kDa), one component of the mitogen-activated protein kinase …
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons …
ZY Zhuang, YR Wen, DR Zhang, T Borsello… - Journal of …, 2006 - Soc Neuroscience
Optimal management of neuropathic pain is a major clinical challenge. We investigated the
involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve …
involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve …
Nociceptor sensitization by extracellular signal-regulated kinases
KO Aley, A Martin, T McMahon, J Mok… - Journal of …, 2001 - Soc Neuroscience
Inflammatory pain, characterized by a decrease in mechanical nociceptive threshold
(hyperalgesia), arises through actions of inflammatory mediators, many of which sensitize …
(hyperalgesia), arises through actions of inflammatory mediators, many of which sensitize …
JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
YJ Gao, L Zhang, OA Samad, MR Suter… - Journal of …, 2009 - Soc Neuroscience
Our previous study showed that activation of c-jun-N-terminal kinase (JNK) in spinal
astrocytes plays an important role in neuropathic pain sensitization. We further investigated …
astrocytes plays an important role in neuropathic pain sensitization. We further investigated …
Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons
S Herrmann, H Rajab, I Christ, C Schirdewahn… - Pain, 2017 - journals.lww.com
Several studies implicated cyclic adenosine monophosphate (cAMP) as an important
second messenger for regulating nociceptor sensitization, but downstream targets of this …
second messenger for regulating nociceptor sensitization, but downstream targets of this …
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
T Mizushima, K Obata, H Yamanaka, Y Dai, T Fukuoka… - Pain, 2005 - Elsevier
Alterations in the intracellular signal transduction pathway in primary afferents may
contribute to pain hypersensitivity. We demonstrated that very rapid phosphorylation of p38 …
contribute to pain hypersensitivity. We demonstrated that very rapid phosphorylation of p38 …
Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization
Y Dai, K Iwata, T Fukuoka, E Kondo… - Journal of …, 2002 - Soc Neuroscience
Alteration in the intracellular signal transduction pathway in primary afferent neurons may
contribute to pain hypersensitivity. We demonstrated that very rapid phosphorylation of …
contribute to pain hypersensitivity. We demonstrated that very rapid phosphorylation of …