Dihydroxyvitamin D3 [1, 25 (OH) 2D3], the biologically active form of vitamin D3, is a
secosteroid hormone essential for bone and mineral homeostasis. It regulates the growth …

Vitamin D has been reported to influence physiological systems that extend far beyond its
established functions in calcium and bone homeostasis. Prominent amongst these are the …

Vitamin D deficiency is an established risk factor for many autoimmune diseases and the
anti-inflammatory properties of vitamin D underscore its potential therapeutic value for these …

Epidemiological evidence indicates a significant association between vitamin D deficiency
and an increased incidence of autoimmune diseases. The presence of vitamin D receptors …

Vitamin D is synthesized from cholesterol in the skin (80–90%) under the sunlight and then
metabolized into an active D hormone in liver, kidney and peripheral immune/inflammatory …

Vitamin D has well-documented effects on calcium homeostasis and bone metabolism but
recent studies suggest a much broader role for this secosteroid in human health. Key …

The classical functions of vitamin D are to regulate calcium-phosphorus homeostasis and
control bone metabolism. However, vitamin D deficiency has been reported in several …

Historically, vitamin D has been associated with the regulation of bone metabolism.
However, increasing evidence demonstrates a strong association between vitamin D …

The active form of vitamin D, 1, 25-Dihydroxyvitamin D3 [1, 25 (OH) 2D3], is a secosteroid
hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear …

Vitamin D deficiency is highly prevalent and is increasingly thought to be an important risk
factor in many diseases that have high morbidity and mortality, including lupus. Vitamin D is …