A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants

JW Kim, HJ Kim, K Heo, Y Lee, HJ Jang… - Frontiers in …, 2023 - frontiersin.org
Introduction The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants has caused unprecedented health and socioeconomic crises, necessitating …

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

X Wang, A Hu, X Chen, Y Zhang, F Yu, S Yue… - … and Targeted Therapy, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic of novel coronavirus disease (COVID-19). The neutralizing monoclonal …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA. 2.86, EG. 5.1, and JN. 1

Z Tong, J Tong, W Lei, Y Xie, Y Cui, G Jia, S Li… - Cell Reports, 2024 - cell.com
The game between therapeutic monoclonal antibodies (mAbs) and continuously emerging
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has favored the …

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent …

J Zang, C Gu, B Zhou, C Zhang, Y Yang, S Xu, L Bai… - Cell Discovery, 2020 - nature.com
Dear Editor, The ongoing coronavirus disease 2019 (COVID-19) pandemic is a serious
public health crisis, which is caused by severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants

JW Kim, K Heo, HJ Kim, Y Yoo, HS Cho, HJ Jang… - Antiviral Research, 2023 - Elsevier
Rapid emergence of new variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has prompted an urgent need for the development of broadly applicable and …

IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

MR Chang, L Tomasovic, NA Kuzmina, AJ Ronk… - Nature …, 2022 - nature.com
Monoclonal antibodies are a promising approach to treat COVID-19, however the
emergence of SARS-CoV-2 variants has challenged the efficacy and future of these …

[HTML][HTML] Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - bioRxiv, 2021 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and
therapeutic antibodies underscores the urgent need for new antibody-based tools that …

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved …

Z Liu, W Xu, Z Chen, W Fu, W Zhan, Y Gao… - Protein & …, 2022 - academic.oup.com
New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to
find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design …

[HTML][HTML] A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants

A Chiyyeadu, G Asgedom, M Bruhn, C Rocha… - Clinical …, 2024 - Elsevier
The devastating impact of COVID-19 on global health shows the need to increase our
pandemic preparedness. Recombinant therapeutic antibodies were successfully used to …