The role of factor V Leiden in maternal health and the outcome of pregnancy

CJ Calderwood, IA Greer - Current Drug Targets, 2005 - ingentaconnect.com
There is growing evidence that women with thrombophilia are at increased risk of pregnancy
related venous thromboembolism and of adverse pregnancy outcome including pregnancy …

The effect of factor V Leiden carriage on maternal and fetal health

D Bloomenthal, P von Dadelszen, R Liston, L Magee… - Cmaj, 2002 - Can Med Assoc
FACTOR V LEIDEN IS A COMMON GENETIC MUTATION that predisposes its carriers to
venous thromboembolism. When combined with the hypercoagulable state that is …

Factor V Leiden mutation and pregnancy-related venous thromboembolism: What is the exact risk?

C Biron-Andreani, JF Schved… - Thrombosis and …, 2006 - thieme-connect.com
The magnitude of the association of factor V Leiden mutation with pregnancy-related venous
thrombosis remains unclear. Our objective was to undertake a systematic review and a meta …

Factor V Leiden in women: a thrombotic risk factor or an evolutionary advantage?

M Franchini, G Lippi - Seminars in thrombosis and hemostasis, 2011 - thieme-connect.com
Factor V Leiden is a common gain-of-function gene mutation resulting in a genetic
predisposition to thromboembolic complications. Growing evidence in the literature indicates …

Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women

D Tormene, P Simioni, P Prandoni, S Luni… - …, 2001 - haematologica.org
BACKGROUND AND OBJECTIVES: In this retrospective, single center, cohort study we
assessed the risk of pregnancy-related venous thromboembolism (VTE) in women …

The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis

TE Dudding, J Attia - Thrombosis and haemostasis, 2004 - thieme-connect.com
The conclusions of studies to date which evaluate a possible association between factor V
Leiden and adverse pregnancy outcome have been conflicting. This study was undertaken …

Obstetric implications of the factor V leiden mutation: a review

D Bloomenthal, MF Delisle, F Tessier… - American journal of …, 2002 - thieme-connect.com
ABSTRACT Factor V Leiden (FVL) is a newly discovered genetic mutation that impairs one
of the body's naturally occurring anticoagulation systems. The result is resistance to …

Factor V Leiden homozygous genotype and pregnancy outcomes

C Biron-Andréani, A Bauters… - Obstetrics & …, 2009 - journals.lww.com
OBJECTIVE: To assess the rate of early (first trimester) and late (second and third trimester)
fetal loss in women who are factor V Leiden homozygous. METHODS: Between December …

The risk of pregnancy‐related venous thromboembolism in women who are homozygous for factor V Leiden

S Middeldorp, EJ Libourel, K Hamulyák… - British journal of …, 2001 - Wiley Online Library
The risk of venous thromboembolism (VTE) is increased in pregnancy and during the post‐
partum period. The absolute risk for pregnancy‐related VTE in heterozygous women with …

Factor V Leiden mutation in pregnancy

SM Cohen - Journal of Obstetric, Gynecologic, & Neonatal …, 2004 - Wiley Online Library
Normal maternal adaptation to pregnancy significantly increases the risk for thrombus
formation. Inherited thrombophilias further increase risk for deep venous thrombosis and …