Cellular immunity is critical for assessing COVID-19 vaccine effectiveness in immunocompromised individuals

E Paramithiotis, S Sugden, E Papp… - Frontiers in …, 2022 - frontiersin.org
COVID-19 vaccine clinical development was conducted with unprecedented speed.
Immunity measurements were concentrated on the antibody response which left significant …

Immunogenicity of COVID-19 vaccination in immunocompromised patients: an observational, prospective cohort study interim analysis

G Haidar, M Agha, A Lukanski, K Linstrum, R Troyan… - MedRxiv, 2021 - medrxiv.org
Objectives Immunocompromised patients were excluded from COVID-19 vaccine clinical
trials. The objectives of the study were to measure antibody responses, levels, and …

The potential danger of suboptimal antibody responses in COVID-19

A Iwasaki, Y Yang - Nature Reviews Immunology, 2020 - nature.com
There is a desperate need for effective therapies and vaccines for SARS-CoV-2 to mitigate
the growing economic crisis that has ensued from societal lockdown. Vaccines are being …

Examining the immunological effects of COVID-19 vaccination in patients with conditions potentially leading to diminished immune response capacity–the OCTAVE …

P Kearns, S Siebert, C Gaskell, A Kirkham, S Pirrie… - 2021 - papers.ssrn.com
SARS-COV-2 vaccines have been shown to be efficacious primarily in healthy volunteer
populations and population level studies. Immune responses following SARS-CoV-2 …

Humoral immune responses in COVID-19 patients: a window on the state of the art

G Siracusano, C Pastori, L Lopalco - Frontiers in immunology, 2020 - frontiersin.org
The novel SARS-CoV-2 is a recently emerging virus causing a human pandemic. A great
variety of symptoms associated with COVID-19 disease, ranging from mild to severe …

Defending against SARS-CoV-2: The T cell perspective

P Almendro-Vázquez, R Laguna-Goya… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …

COVID-19 vaccines: Immune correlates and clinical outcomes

SH Mahrokhian, LH Tostanoski, SJ Vidal… - Human Vaccines & …, 2024 - Taylor & Francis
Severe disease due to COVID-19 has declined dramatically as a result of widespread
vaccination and natural immunity in the population. With the emergence of SARS-CoV-2 …

Characterization of SARS-CoV-2-Specific humoral and cellular immune responses induced by inactivated COVID-19 vaccines in a real-world setting

Z Li, T Xiang, B Liang, H Deng, H Wang… - Frontiers in …, 2021 - frontiersin.org
While the immunogenicity of inactivated vaccines against coronavirus disease 2019 (COVID‐
19) has been characterized in several well-conducted clinical trials, real-world evidence …

Immune Responses against SARS-CoV-2—Questions and Experiences

H Mangge, M Kneihsl, W Schnedl, G Sendlhofer… - Biomedicines, 2021 - mdpi.com
Understanding immune reactivity against SARS-CoV-2 is essential for coping with the
COVID-19 pandemic. Herein, we discuss experiences and open questions about the …

Cellular and humoral immune responses in covid-19 and immunotherapeutic approaches

A Hasan, E Al-Ozairi, Z Al-Baqsumi… - ImmunoTargets and …, 2021 - Taylor & Francis
Abstract Coronavirus disease 2019 (Covid-19), caused by the novel coronavirus severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can range in severity from …