Leptin is a hormone secreted by adipose tissue in direct proportion to amount of body fat.
The circulating leptin levels serve as a gauge of energy stores, thereby directing the …

Purpose: To review recent advances in the pathophysiology and potential clinical
applications of leptin, an adipose tissue-derived hormone. Data Sources: A MEDLINE …

Leptin is an adipose tissue hormone that functions as an afferent signal in a negative
feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …

Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis. Studies in
animal models, in humans with congenital complete leptin deficiency, and observational and …

Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and
metabolic functions. In this review, we describe the role of leptin in human physiology and …

The hyperphagia, low sympathetic nervous system tone, and decreased circulating
concentrations of bioactive thyroid hormones that are common to states of congenital leptin …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin is an adipokine and its name derives from the Greek word lepto 2 (leptos), which
means thin. Since its initial discovery in 1994, important advances have been made, and …

Obesity is a prevalent condition that is reaching epidemic proportions in the United States.
Sixty-three percent of men and 55% of women are overweight [body mass index (BMI) of 25 …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …