CS Mantzoros - Annals of internal medicine, 1999 - acpjournals.org
Purpose: To review recent advances in the pathophysiology and potential clinical applications of leptin, an adipose tissue-derived hormone. Data Sources: A MEDLINE …
J Friedman - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
Leptin is an adipose tissue hormone that functions as an afferent signal in a negative feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …
AM Brennan, CS Mantzoros - Nature clinical practice Endocrinology & …, 2006 - nature.com
Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis. Studies in animal models, in humans with congenital complete leptin deficiency, and observational and …
TA Dardeno, SH Chou, HS Moon… - Frontiers in …, 2010 - Elsevier
Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and …
M Rosenbaum, RL Leibel - Journal of Endocrinology, 2014 - joe.bioscientifica.com
The hyperphagia, low sympathetic nervous system tone, and decreased circulating concentrations of bioactive thyroid hormones that are common to states of congenital leptin …
Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted hormone with pleiotropic effects in the physiology and pathophysiology of energy …
Leptin is an adipokine and its name derives from the Greek word lepto 2 (leptos), which means thin. Since its initial discovery in 1994, important advances have been made, and …
CS Mantzoros, JS Flier - The Journal of Clinical Endocrinology & …, 2000 - academic.oup.com
Obesity is a prevalent condition that is reaching epidemic proportions in the United States. Sixty-three percent of men and 55% of women are overweight [body mass index (BMI) of 25 …
Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central …