In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

It is now widely recognized that primary aldosteronism (PA) is much more common than
previously thought, accounting for up to 5–10% of hypertensives, and that aldosterone …

Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

Primary aldosteronism (PA) is a condition well worth detecting because it is a common
cause of hypertension and is associated with excessive morbidity for the degree of …

Context New approaches are needed to address the evolution of the primary aldosteronism
syndrome and to increase its recognition. Herein, we review evidence indicating that primary …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Primary aldosteronism (PA) secondary to excessive and/or autonomous aldosterone
secretion from the renin–angiotensin system accounts for∼ 10% of cases of hypertension …

Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

Background Primary aldosteronism is much more common than previously held; it implies
an excessive organ damage to the heart, vessels and kidney, which translates into an …