Electrical stimulation increases matrix metalloproteinase‐2 gene expression but does not change its activity in denervated rat muscle

TL Russo, SM Peviani, JLQ Durigan… - Muscle & Nerve …, 2008 - Wiley Online Library
Muscle‐fiber atrophy occurs concomitantly with intramuscular connective tissue proliferation
following denervation. These events contribute to the impairment of mechanical and …

Stretching and electrical stimulation regulate the metalloproteinase-2 in rat denervated skeletal muscle

SM Peviani, TL Russo, JLQ Durigan… - Neurological …, 2010 - Taylor & Francis
Objective: To evaluate the effects of electrical stimulation (ES), stretching and their combined
effects in matrix metalloproteinases (MMPs) gene expression and activity during early …

Characterization of matrix metalloproteinases in denervated muscle

M Demestre, M Orth, GM Wells… - Neuropathology and …, 2005 - Wiley Online Library
In a nerve crush model of denervation, we examined muscle matrix metalloproteinase
(MMP) expression, localization and activity. In normal muscle, MMP mRNA levels were low …

Electrical stimulation of denervated rat skeletal muscle retards capillary and muscle loss in early stages of disuse atrophy

K Nakagawa, H Tamaki, K Hayao… - BioMed Research …, 2017 - Wiley Online Library
The purpose of the present study is to investigate the effects of low‐frequency electrical
muscle stimulation (ES) on the decrease in muscle mass, fiber size, capillary supply, and …

Matrix metalloproteinases MMP-2, MMP-7 and MMP-9 in denervated human muscle

BGH Schoser, D Blottner - Neuroreport, 1999 - journals.lww.com
PROTEOLYTIC enzyme expression was studied by matrix metalloproteinases (MMP)
immunoreactivity (-IR) in muscle biopsies from patients with amyotrophic lateral sclerosis …

Pattern of metalloprotease activity and myofiber regeneration in skeletal muscles of mdx mice

C Bani, J Lagrota‐Candido, DF Pinheiro… - Muscle & Nerve …, 2008 - Wiley Online Library
Matrix metalloproteases (MMPs) are key regulatory molecules in the formation, remodeling,
and degradation of extracellular matrix components in both physiological and pathological …

Type IV collagen and its degradation in paralyzed human muscle: effect of functional electrical stimulation

SOA Koskinen, M Kjær, T Mohr… - Muscle & Nerve …, 2000 - Wiley Online Library
The purpose of this study was to evaluate the effects of spinal cord injury (SCI) and
functional electrical stimulation (FES) of paralyzed muscles on type IV collagen content and …

Electrical stimulation of denervated rat skeletal muscle ameliorates bone fragility and muscle loss in early-stage disuse musculoskeletal atrophy

H Tamaki, K Yotani, F Ogita, K Hayao… - Calcified tissue …, 2017 - Springer
We tested whether daily muscle electrical stimulation (ES) can ameliorate the decrease in
cortical bone strength as well as muscle and bone geometric and material properties in the …

Regulation of connective tissue remodeling in the early phase of denervation in a rat skeletal muscle

J Ozawa, T Kurose, S Kawamata, A Kaneguchi… - Biomedical …, 2013 - jstage.jst.go.jp
Denervation alters the metabolism of the extracellular matrix (ECM) in skeletal muscle;
however, the underlying mechanisms of ECM remodeling are not fully understood. The aim …

Matrix metalloproteinases and skeletal muscle: a brief review

E Carmeli, M Moas, AZ Reznick… - Muscle & Nerve: Official …, 2004 - Wiley Online Library
Matrix metalloproteinases (MMPs) are a family of zinc‐dependent proteolytic enzymes that
function mainly in the extracellular matrix, where they contribute to the development …