Transcriptional profiling of human uveal melanoma from cell lines to intraocular tumors to metastasis

JC Marshall, A Nantel, P Blanco, J Ash… - Clinical & experimental …, 2007 - Springer
Uveal melanoma is the most common primary intraocular tumor in adults and exclusively
disseminates haematogenously in order to form metastases. The aim of this study was to …

Significance of gene expression analysis in uveal melanoma in comparison to standard risk factors for risk assessment of subsequent metastases

U Petrausch, P Martus, H Tönnies, NE Bechrakis… - Eye, 2008 - nature.com
Significance of gene expression analysis in uveal melanoma in comparison to standard risk
factors for risk assessment of subsequent metastases | Eye Skip to main content Thank you for …

[HTML][HTML] Tissue-based microarray expression of genes predictive of metastasis in uveal melanoma and differentially expressed in metastatic uveal melanoma

H Demirci, D Reed, VM Elner - Journal of Ophthalmic & Vision …, 2013 - ncbi.nlm.nih.gov
Purpose To screen the microarray expression of CDH1, ECM1, EIF1B, FXR1, HTR2B, ID2,
LMCD1, LTA4H, MTUS1, RAB31, ROBO1, and SATB1 genes which are predictive of primary …

[HTML][HTML] Repression of genes involved in melanocyte differentiation in uveal melanoma

MA Bergeron, S Champagne, M Gaudreault… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose Uveal melanoma (UM) has been the subject of intense interest due to its distinctive
metastatic pattern, which involves hematogenous dissemination of cancerous cells toward …

Molecular determinants of human uveal melanoma invasion and metastasis

EA Seftor, PS Meltzer, DA Kirschmann, J Pe'er… - Clinical & experimental …, 2002 - Springer
The molecular analysis of cancer has benefited tremendously from the sequencing of the
human genome integrated with the science of bioinformatics. Microarray analysis …

[HTML][HTML] Effects of long-term serial passaging on the characteristics and properties of cell lines derived from uveal melanoma primary tumors

F Mouriaux, K Zaniolo, MA Bergeron… - … & Visual Science, 2016 - arvojournals.org
Purpose: Development of liver metastasis remains the most common cause of mortality in
uveal melanoma (UM). A few cell lines cultured from primary UM tumors have been used …

Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not

A Linge, S Kennedy, D O'Flynn, S Beatty… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: To compare the proteomic profiles of two categories of primary uveal melanoma
tissue samples; those from patients who have subsequently developed metastatic disease …

Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development

W Zuidervaart, PA Van Der Velden, MH Hurks… - British journal of …, 2003 - nature.com
Microarray is a powerful tool to compare the gene expression of different tumour specimens
and cell lines simultaneously and quantitatively. To get a better insight into genes that are …

Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling

LA Worley, MD Long, MD Onken… - Melanoma research, 2008 - journals.lww.com
Uveal (ocular) melanoma is a highly aggressive cancer that leads to metastatic death in up
to half of patients despite successful local therapy. Biomarkers of metastatic risk are critically …

Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens

MD Onken, LA Worley, RM Dávila, DH Char… - The Journal of Molecular …, 2006 - Elsevier
Many uveal melanoma patients die of metastasis despite ocular treatment. Transcriptomic
profiling of enucleated tumors can identify patients at high metastatic risk. Because most …