Although the study of embryonic kidney development began in the 1950s, three decades
passed until scientists began identifying the molecular controls of renal organogenesis. Most …

The development of the mature mammalian kidney begins with the invasion of metanephric
mesenchyme by ureteric bud. Mesenchymal cells near the bud become induced and convert …

The kidney has been used for the last 50 years as a model system for the study of tissue
inductions and vertebrate organogenesis. While much is known about the morphologic …

Although it is not easy to investigate the regulatory basis of developmental processes in
most mammalian tissues, the mouse kidney has several distinct advantages as a model …

The functional mass of kidney tissue in an adult is an important determinant of human
health. Kidney formation during development is an essential determinant of the final …

Transgenic animal technology, which allows the germline insertion of exogenous genes or
the alteration or disruption of endogenous genes, has emerged as a powerful tool for the in …

The functional unit of the kidney is the nephron. During its organogenesis, the mammalian
metanephric kidney generates thousands of nephrons over a protracted period of fetal life …

Thousands of genes show differential expression patterns during kidney development,
suggesting that the genetic program driving this process is complex. While great progress …

Over the recent decades there has been extensive investigation into the genetic/molecular
regulation and cellular/molecular mechanisms of nephrogenesis and ultimate kidney …

The molecular basis of the organogenesis of the mammalian kidney is being investigated at
multiple levels, with several exciting developments. Cellular signaling during and after …