Background Recent studies show that inflammatory processes may contribute to
neuropathic pain. Cyclooxygenase-2 (Cox-2) is an inducible enzyme responsible for …

Immunohistochemistry was used to examine the expression of prostaglandin E2 receptors
EP1 and EP4 in sciatic nerves from the rat chronic constriction injury (CCI) model of …

We previously reported that cyclooxygenase 2 (COX2) is up-regulated in macrophages in
injured nerve of rats with partial sciatic nerve ligation (PSNL) and that local injection of the …

Neuropathic pain (NeP) is a common chronic pain state with unmet medical needs. Due to
poorly defined underlying mechanisms, current therapies for NeP are far from satisfactory …

Abstract Prostaglandin E2 (PGE2), a well-known pain mediator enriched in inflamed tissues,
plays a pivotal role in the genesis of chronic pain conditions such as inflammatory and …

Prostaglandin (PG) E 2 is an important lipid mediator that is involved in several
pathophysiological processes contributing to fever, inflammation, and pain. Previous studies …

We previously reported the up-regulation of cyclooxygenase 2 (COX2) in injured sciatic
nerve of rats with partial sciatic nerve ligation (PSNL) and the reversal of PSNL-elicited …

Inflammatory mediators produced in the injured nerve have been proposed as contributing
factors in the development of neuropathic pain. Prostaglandins (PGs) are probably included …

J. Neurochem.(2011) 118, 841–854. Abstract Following various types of nerve injury,
cyclooxygenase 2 and prostaglandin E2 (PGE2) are universally and chronically up …

Inflammation associated with nerve injury produces a number of pathogenic chemical
mediators of which prostanoids are a potent component. Cyclooxygenases (Cox‐1 and Cox …