Cancer is a major cause of global mortality underpinned by genomic and epigenomic
derangements. Here, we highlight the importance of multimodal data integration in …

Advances in high-throughput, genome-wide profiling technologies have allowed for an
unprecedented view of the cancer genome landscape. Specifically, high-density microarrays …

The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …

Progress in DNA sequencing has revealed the startling complexity of cancer genomes,
which typically carry thousands of somatic mutations. However, it remains unclear which are …

Cancer represents an evolutionary process through which growing malignant populations
genetically diversify, leading to tumour progression, relapse and resistance to therapy. In …

Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic …

Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …

Tumor initiation and progression are somatic evolutionary processes driven by the
accumulation of genetic alterations, some of which confer selective fitness advantages to the …

Precision medicine requires an understanding of cancer genes and mutational processes,
as well as an appreciation of the extent to which these are found heterogeneously in cancer …

Cancers are characterized by extensive heterogeneity that occurs intratumorally, between
lesions, and across patients. To study cancer as a complex biological system …