Hypothermia is a critical consequence of extreme cold exposure that increases the risk of
cold-related injury and death in humans. While the initiation of cytoprotective mechanisms …

With the increasing threat of climate change and the accompanying rise in the frequency
and severity of extreme heat events, there are growing health concerns for heat-vulnerable …

Under conditions of extreme heat stress, the process of autophagy has previously been
shown to protect human cells, but the exact body temperature at which autophagic activation …

Heat waves can cause dangerous elevations in body temperature that can compromise
cellular function and increase the risk of heat stroke and major cardiovascular events …

With rising global temperatures, heat-related mortality is increasing, particularly among older
adults. Although this is often attributed to declines in thermoregulatory function, little is …

To protect vulnerable populations during heat waves, public health agencies recommend
maintaining indoor air temperature below∼ 24–28° C. While we recently demonstrated that …

Heat-stress-induced dehydration is associated with extracellular hyperosmolality. To
counteract the associated stress, cells employ cytoprotective mechanisms, including …

Temperature variations in cells, tissues and organs may occur in a number of circumstances.
We report here that reducing temperature of cells in culture to 25° C for 5 days followed by a …

Hyperthermia is a promising anticancer treatment used in combination with radiotherapy
and chemotherapy. Temperatures above 41.5° C are cytotoxic and hyperthermia treatments …

The exposure to low doses of stress induces an adaptive survival response that involves
upregulation of cellular defense systems such as heat shock proteins (Hsp), anti-apoptosis …