Osteopetrosis is a metabolic bone disease characterized by excessive accumulation of
skeletal mass due to a reduction in bone resorption. The pathogenesis of osteopetrosis is …

Progress has been made in recent years on the cell biology of the osteoclast and the
pathogenesis of congenital osteopetrosis. New information is critically evaluated and …

Osteopetrosis is a metabolic bone disease characterized by reduced bone resorption. From
experimental studies of various osteopetrotic mutations has emerged the hypothesis that …

Osteopetrosis is a metabolic bone disease characterized by a systemic increase in skeletal
mass. It results from a defect in the production or function of osteoclasts and is inherited in …

Osteopetrosis, a metabolic bone disease characterized by a generalized sclerosis of the
skeleton, is inherited as an autosomal recessive in a number of mammalian species. The …

Osteopetrosis describes a heterogeneous group of congenital bone disorders characterized
by a generalized increase in skeletal mass resulting from a primary reduction in osteoclast …

Osteopetrosis is a metabolic bone disease inherited in a number of species including
human beings and characterized by a generalized increase in skeletal density detected …

Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of
osteopetrosis have provided instrumental information on bone remodeling, including the …

In order to investigate the ultrastructure of bone resorptive cells in the two types of adult
benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 …

Throughout life, bone tissue is in a constant state of turnover. This process of bone
remodeling is the result of a combination of sequential removal of bone tissue by osteoclasts …