The replacement of hydrogen with fluorine in organic molecules can profoundly influence their chemical and physical properties, leading to a range of compounds with highly …
KL Kirk - Journal of Fluorine Chemistry, 2006 - Elsevier
Advances in the development of newly developed fluorinated drugs, approved or in clinical trials, as organized by biological targets/disease states, are reviewed. In a few cases …
JP Bégué, D Bonnet-Delpon - 2008 - books.google.com
Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated …
Drug candidates with one or more fluorines have become commonplace. The special nature of fluorine imparts a variety of properties to certain medicines, including enhanced binding …
In view of increasing interest in organofluorine compounds, this book was undertaken to describe biological and physical properties of organofluorine compounds, synthetic methods …
T Yamazaki, T Taguchi, I Ojima - Fluorine in medicinal chemistry …, 2009 - books.google.com
The natural abundance of fluorine as fluorite, fluoroapatite, and cryolite is considered to be at the same level as that of nitrogen on the basis of the Clarke number of 0.03. However …
The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine …
D O'Hagan - Journal of Fluorine Chemistry, 2010 - Elsevier
Organic fluorine compounds have had a profound impact on the development of bioactives for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals …
J Han, AM Remete, LS Dobson, L Kiss, K Izawa… - Journal of Fluorine …, 2020 - Elsevier
The role of organo-fluorine compounds in modern health, food and energy related industries is widely-appreciated. The unique properties that fluorine imparts to organic molecules …