Single-cell immunology of SARS-CoV-2 infection

Y Tian, LN Carpp, HER Miller, M Zager… - Nature …, 2022 - nature.com
Gaining a better understanding of the immune cell subsets and molecular factors associated
with protective or pathological immunity against severe acute respiratory syndrome …

Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms

B Brown, V Ojha, I Fricke, SA Al-Sheboul, C Imarogbe… - Vaccines, 2023 - mdpi.com
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Single-cell multi-omics analysis of the immune response in COVID-19

E Stephenson, G Reynolds, RA Botting… - Nature medicine, 2021 - nature.com
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

[HTML][HTML] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

X Ren, W Wen, X Fan, W Hou, B Su, P Cai, J Li, Y Liu… - Cell, 2021 - cell.com
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

D Mathew, JR Giles, AE Baxter, DA Oldridge… - Science, 2020 - science.org
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

AJ Wilk, MJ Lee, B Wei, B Parks, R Pi… - Journal of Experimental …, 2021 - rupress.org
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

[HTML][HTML] Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients

L Zhu, P Yang, Y Zhao, Z Zhuang, Z Wang, R Song… - Immunity, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic poses a current world-wide
public health threat. However, little is known about its hallmarks compared to other infectious …

Single-cell landscape of immunological responses in patients with COVID-19

JY Zhang, XM Wang, X Xing, Z Xu, C Zhang… - Nature …, 2020 - nature.com
Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …

Immune response in severe and non-severe coronavirus disease 2019 (COVID-19) infection: a mechanistic landscape

K Mukund, P Nayak, C Ashokkumar, S Rao… - Frontiers in …, 2021 - frontiersin.org
The mechanisms underlying the immune remodeling and severity response in coronavirus
disease 2019 (COVID-19) are yet to be fully elucidated. Our comprehensive integrative …

[HTML][HTML] Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19

JP Bernardes, N Mishra, F Tran, T Bahmer, L Best… - Immunity, 2020 - cell.com
Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …