NF-κB regulates normal and pathological processes, including neoplasia, in a tissue-context-
dependent manner. In skin, NF-κB is implicated in epidermal homeostasis as well as in the …

The transcription factor AP-1 (activator protein-1) regulates a number of genes that drive
tumor promotion and progression. While basal levels of AP-1 activity are important for …

Upregulation of TNF-α is a key early response to ultraviolet B (UVB) by keratinocytes (KCs),
and represents an important component of the inflammatory cascade in skin. UVB irradiation …

Our previous study shows that inhibiting activator protein one (AP1) transcription factor
function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell …

Nuclear factor κB (NF-κB) gene-regulatory proteins play important roles in inflammation,
neoplasia, and programmed cell death. Recently, blockade of NF-κB function has been …

Many tumors show a mutant or inactive tumor suppressor p53 (TP53) status, and TP53 in the
tumor-carrying human papillomavirus (HPV) may be dysfunctional because of inhibition by …

The skin constitutes a primary target for stimuli such as ultraviolet (UV) radiation and tumor
promoters, leading to both inflammatory and altered proliferative responses. Since the …

Deregulation of the activator protein 1 (AP1) family gene regulators has been implicated in a
wide range of diseases, including cancer. In this study we report that c-Jun was activated in …

The nuclear factor kappa B (NF‐κB) signalling pathway exhibits both tumour‐promoting and
tumour‐suppressing functions in different tissues and models of carcinogenesis. In particular …

We have stably expressed a trans-activation suppressing deletion mutant of the human c-jun
gene (TAM-67) in the malignant mouse epidermal cell lines 10Gy5 and PDV. Expression of …