To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in
skin, transgenic mice were generated, which use the tetracycline system to conditionally …

The NF-κB pathway plays a critical role in regulating cellular processes such as immune
responses, stress responses, apoptosis, proliferation and differentiation, whereas …

The role of the transcription factor NF-κB in shaping the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …

The p53 homologue p63 encodes multiple protein isoforms either with (TA) or without (ΔN)
the N‐terminal transactivation domain. Accumulating evidence indicates that TAp63 plays …

The basal transcription of the CXC chemokine, melanocyte growth stimulatory activity
(MGSA)/growth-regulated protein (GRO)-α, is up-regulated in Hs294T melanoma cells …

The constitutive activation of nuclear factor κB (NFκB) helps a variety of tumors to resist
apoptosis and desensitizes them to chemotherapy, but the causes are still largely unknown …

Background Nuclear factor‐κB (NF‐κB) is a transcription factor involved in a number of
signalling pathways in many cell types. NF‐κB in mice has been implicated as an important …

Purpose: Aberrant nuclear activation and phosphorylation of the canonical NF-κB subunit
RELA/p65 at Serine-536 by inhibitor κB kinase is prevalent in head and neck squamous cell …

In several squamous cell carcinoma (SCC) cells, it has been previously observed that
induction of the S100 calcium-binding protein A7 (S100A7) is repressed by YAP via the …

Numerous observations indicate a strong link between chronic inflammation and cancer.
This link is supported by substantial experimental evidence indicating mutual negative …