Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their …
The disease caused by SARS-CoV2, covid-19, rapidly spreads worldwide, causing the
greatest threat to global public health in the last 100 years. This scenario has become …
greatest threat to global public health in the last 100 years. This scenario has become …
[HTML][HTML] In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication
A novel coronavirus, named SARS-CoV-2, emerged in 2019 in China and rapidly spread
worldwide. As no approved therapeutics exists to treat COVID-19, the disease associated to …
worldwide. As no approved therapeutics exists to treat COVID-19, the disease associated to …
[HTML][HTML] Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome
Abstract The coronavirus disease 2019 (COVID-19) pandemic has heavily challenged the
global healthcare system. Despite the vaccination programs, the new virus variants are …
global healthcare system. Despite the vaccination programs, the new virus variants are …
Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies
The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
necessitates the rapid development of new therapies against coronavirus disease 2019 …
necessitates the rapid development of new therapies against coronavirus disease 2019 …
[HTML][HTML] Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence
Since the 2019 novel coronavirus disease (COVID-19) outbreak in 2019 and the pandemic
continues for more than one year, a vast amount of drug research has been conducted and …
continues for more than one year, a vast amount of drug research has been conducted and …
[HTML][HTML] Network bioinformatics analysis provides insight into drug repurposing for COVID-19
X Li, J Yu, Z Zhang, J Ren, AE Peluffo, W Zhang… - Medicine in Drug …, 2021 - Elsevier
The COVID-19 disease caused by the SARS-CoV-2 virus is a health crisis worldwide. While
developing novel drugs and vaccines is long, repurposing existing drugs against COVID-19 …
developing novel drugs and vaccines is long, repurposing existing drugs against COVID-19 …
[HTML][HTML] Drug repurposing for COVID-19 using graph neural network with genetic, mechanistic, and epidemiological validation
Amid the pandemic of 2019 novel coronavirus disease (COVID-19) infected by SARS-CoV-
2, a vast amount of drug research for prevention and treatment has been quickly conducted …
2, a vast amount of drug research for prevention and treatment has been quickly conducted …
[HTML][HTML] Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model
Background Drug repurposing is a fast and effective way to develop drugs for an emerging
disease such as COVID-19. The main challenges of effective drug repurposing are the …
disease such as COVID-19. The main challenges of effective drug repurposing are the …
[HTML][HTML] Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease
The COVID-19 pandemic has highlighted the urgent need for the identification of new
antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the …
antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the …
[HTML][HTML] Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …