Systems biology offers considerable promise in uncovering novel pathways by which
viruses and other microbial pathogens interact with host signaling and expression networks …

Severe acute respiratory syndrome coronavirus (SARS-CoV) infection often caused severe
end stage lung disease and organizing phase diffuse alveolar damage, especially in the …

Human lung epithelial cells are likely among the first targets to encounter invading severe
acute respiratory syndrome-associated coronavirus (SARS-CoV). Not only can these cells …

To identify host factors relevant for severe acute respiratory syndrome-coronavirus (SARS-
CoV) replication, we performed a small interfering RNA (siRNA) library screen targeting the …

Background The complex interplay between viral replication and host immune response
during infection remains poorly understood. While many viruses are known to employ anti …

Severe acute respiratory syndrome (SARS), which is caused by a novel coronavirus (CoV),
is a highly communicable disease with the lungs as the major pathological target. Although …

Our knowledge regarding immune-protective and immunopathogenic events in severe acute
respiratory syndrome coronavirus (SARS-CoV) infection is limited, and little is known about …

Several respiratory viruses, including influenza virus and severe acute respiratory syndrome
coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular …

Highly pathogenic human respiratory coronaviruses cause acute lethal disease
characterized by exuberant inflammatory responses and lung damage. However, the factors …

The modulation of the immune response is a common practice of many highly pathogenic
viruses. The emergence of the highly pathogenic coronavirus severe acute respiratory virus …